Muangthong United have drawn to play Mahasarakham Football Club (MSKFC), or 'the great purple crabs' as the team is nicknamed, in the next round of the Chang FA Cup, 2021-22.

Muangthong United had defeated MH Nakhon Si from the southern Thailand province of Surat Thani in order to advance to the round of 32. MSKFC play in Thailand's third division and are based out of the northeastern province that goes by the same name.